1 Swelling. Most people typically have some degree of leg swelling, especially near the end of the day. ...
2 Leg pain. New leg pain — such as a calf cramp or charley horse — could signal a blood clot in the leg. ...
3 Varicose vein changes. ...
4 Shortness of breath. ...
5 Chest pain. ...
6 Coughing up blood.
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